CHAPTER XI: ANALYSIS AND CONTROL OF ALIPHATIC PHARMACEUTICAL PREPARATIONS
Section outline
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Aliphatic compounds, characterized by carbon atoms arranged in straight or branched chains, or non-aromatic rings, form a foundational class of molecules in pharmaceutical science. Unlike their aromatic counterparts with rigid, delocalized electron systems, aliphatic molecules exhibit greater conformational flexibility, which directly influences their physicochemical properties, biological interactions, and analytical behavior. This category encompasses a vast range of substances, from simple hydrocarbon gases to complex macromolecules. The analysis of these preparations is critical, as their properties can dictate drug delivery, stability, and efficacy. This chapter is dedicated to the analytical strategies for four critically important sub-classes of aliphatic pharmaceuticals: alcohols, ethers, halogenated derivatives, and urea derivatives.
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By the end of this chapter, the student will be able to:
v Categorize the fundamental roles of aliphatic compounds specifically halogenated derivatives, alcohols, ethers, and urea derivatives as Active Pharmaceutical Ingredients, excipients, and impurities in pharmaceutical formulations.
v Design a strategic analytical workflow for the quality control of a pharmaceutical preparation containing aliphatic compounds, ensuring identity, potency, purity, and safety in compliance with regulatory standards.
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